Macrophage Pyroptosis in Promoting the Occurrence and Development of Atherosclerosis
Atherosclerosis is a chronic disease that threatens human life and health.Macrophage,as an important mediator of inflammatory response,is involved in the development of atherosclerosis.Pyroptosis is a key cause of macrophage death in atherosclerotic plaques.In recent years,it has been found that macrophage pyroptosis is an important mechanism to promote the occurrence and development of atherosclerosis,and the caspase-1-GSDMD mediated macrophage pyroptosis pathway plays a key role in atherosclerosis.Therefore,alleviating macrophage pyroptosis is a potential therapeutic target for reversing atherosclerosis.This article mainly reviews the promotion of macrophage pyroptosis in the occurrence and development of atherosclerosis and the treatment prospects of related inhibitors.
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