巨噬细胞焦亡促进动脉粥样硬化发生发展的作用及其机制研究进展
Macrophage Pyroptosis in Promoting the Occurrence and Development of Atherosclerosis
周梦丹 1李库林 1王如兴1
作者信息
- 1. 南京医科大学附属无锡市人民医院心血管内科,江苏无锡 214000
- 折叠
摘要
动脉粥样硬化是一种危害人类生命健康的慢性疾病.巨噬细胞作为炎症反应的重要介质,参与动脉粥样硬化发生发展.近年来研究发现,巨噬细胞焦亡是促进动脉粥样硬化发生发展的重要机制,其中胱天蛋白酶-1-Gasdermin家族介导的巨噬细胞焦亡在动脉粥样硬化中起到关键作用.因此减轻巨噬细胞焦亡可能是逆转动脉粥样硬化的潜在治疗靶点.现主要综述巨噬细胞焦亡促进动脉粥样硬化发生发展及其相关抑制药物的治疗前景.
Abstract
Atherosclerosis is a chronic disease that threatens human life and health.Macrophage,as an important mediator of inflammatory response,is involved in the development of atherosclerosis.Pyroptosis is a key cause of macrophage death in atherosclerotic plaques.In recent years,it has been found that macrophage pyroptosis is an important mechanism to promote the occurrence and development of atherosclerosis,and the caspase-1-GSDMD mediated macrophage pyroptosis pathway plays a key role in atherosclerosis.Therefore,alleviating macrophage pyroptosis is a potential therapeutic target for reversing atherosclerosis.This article mainly reviews the promotion of macrophage pyroptosis in the occurrence and development of atherosclerosis and the treatment prospects of related inhibitors.
关键词
巨噬细胞/细胞焦亡/动脉粥样硬化/胱天蛋白酶Key words
Macrophage/Pyroptosis/Atherosclerosis/Caspase引用本文复制引用
出版年
2024
NETL
NSTL
万方数据