p300/CBP调控心脏衰老及其相关疾病的机制
Mechanisms of p300/CBP in Regulating Cardiac Aging and Associated Diseases
贺文超 1张正义1
作者信息
- 1. 兰州大学第二医院第二临床医学院,甘肃兰州 730000
- 折叠
摘要
随着人口老龄化的不断发展,心脏衰老导致心脏肥大、心肌纤维化增加、电信号传导异常等病理变化所引起的心血管疾病发病率逐年升高.以p300/CBP为主的组蛋白乙酰转移酶介导的表观遗传调控在其发病过程起重要作用.现总结目前关于p300/CBP的结构、功能、调控心血管疾病发展的作用机制及其靶向药物的研究现状,并对其未来的应用和发展前景进行展望,为治疗心脏衰老相关的疾病提供新的思路.
Abstract
With the continuous development of the aging population,the incidence of cardiovascular diseases caused by pathological changes such as cardiac hypertrophy,increased myocardial fibrosis,and abnormal electrical signal conduction due to cardiac aging is rising year by year.Histone acetyltransferases,especially p300/CBP,play a significant role in the pathogenesis of these diseases through epigenetic regulation.This summary reviews the current research on the structure,function,mechanisms of action in the development of cardiovascular diseases,and the current status of research on targeted drugs for p300/CBP.It also provides an outlook on future applications and prospects,offering new perspectives for the treatment of cardiac age related diseases.
关键词
组蛋白乙酰转移酶/p300/CBP/心脏衰老/心房颤动Key words
Histone acetyltransferase/p300/CBP/Cardiac aging/Atrial fibrillation引用本文复制引用
出版年
2024
NETL
NSTL
万方数据