Mechanisms of p300/CBP in Regulating Cardiac Aging and Associated Diseases
With the continuous development of the aging population,the incidence of cardiovascular diseases caused by pathological changes such as cardiac hypertrophy,increased myocardial fibrosis,and abnormal electrical signal conduction due to cardiac aging is rising year by year.Histone acetyltransferases,especially p300/CBP,play a significant role in the pathogenesis of these diseases through epigenetic regulation.This summary reviews the current research on the structure,function,mechanisms of action in the development of cardiovascular diseases,and the current status of research on targeted drugs for p300/CBP.It also provides an outlook on future applications and prospects,offering new perspectives for the treatment of cardiac age related diseases.
NETL
NSTL
万方数据
