Feasibility and Practice of Assessing Cardiovascular Risk and Prognosis Through Estimated Pulse Wave Velocity
Objective Assessing the feasibility of estimated pulse wave velocity(ePWV)in predicting cardiovascular risk and prognosis,and its clinical applications.Methods Data from the National Health and Nutrition Examination Survey(1999-2018)were analyzed.Cardiovascular risk factors were assessed,and the Framingham risk score(FRS)was calculated.Cox proportional hazards models were used with all-cause mortality and cardiovascular mortality as outcomes.Harrell's C-statistic was employed to evaluate the additional predictive value of ePWV.Results The association between ePWV and outcomes remained significant after adjusting for cardiovascular risk factors(HR=1.33,95％CI 1.21～1.50 for all-cause mortality,HR=1.51,95％CI 1.30～1.78 for cardiovascular mortality)and FRS(HR=1.22,95％CI 1.12～1.32 for all-cause mortality,HR=1.32,95％CI 1.10～1.59 for cardiovascular mortality).The model incorporating ePWV showed a higher Harrell's C-statistic compared to models with FRS or cardiovascular risk factors(P＜0.05).Conclusion ePWV could serve as a non-invasive,convenient and practical clinical parameter for assessing cardiovascular risk and prognosis.
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