Objective Assessing the feasibility of estimated pulse wave velocity(ePWV)in predicting cardiovascular risk and prognosis,and its clinical applications.Methods Data from the National Health and Nutrition Examination Survey(1999-2018)were analyzed.Cardiovascular risk factors were assessed,and the Framingham risk score(FRS)was calculated.Cox proportional hazards models were used with all-cause mortality and cardiovascular mortality as outcomes.Harrell's C-statistic was employed to evaluate the additional predictive value of ePWV.Results The association between ePWV and outcomes remained significant after adjusting for cardiovascular risk factors(HR=1.33,95％CI 1.21～1.50 for all-cause mortality,HR=1.51,95％CI 1.30～1.78 for cardiovascular mortality)and FRS(HR=1.22,95％CI 1.12～1.32 for all-cause mortality,HR=1.32,95％CI 1.10～1.59 for cardiovascular mortality).The model incorporating ePWV showed a higher Harrell's C-statistic compared to models with FRS or cardiovascular risk factors(P＜0.05).Conclusion ePWV could serve as a non-invasive,convenient and practical clinical parameter for assessing cardiovascular risk and prognosis.
NETL
NSTL
万方数据
