Objective:To investigate the effects of dyslipidemia on exercise tolerance in patients with coronary heart disease(CHD).Methods:A total of 297 CHD patients,who were treated in Department of Cardiology of People's Hos-pital of Yuxi City from January 2019 to January 2020,were recruited.Patients were divided into normal exercise tolerance group(n=43)and reduced exercise tolerance group(n=254)according to whether the VO2/kg@AT％Pred＜80％.Gen-eral data,levels of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL—C),low density lipoprotein cholesterol(LDL—C)and very low density lipoprotein cholesterol(vLDL—C)were compared and analyzed between two groups.Influencing factors for reduced exercise tolerance in CHD patients were analyzed,and the ROC curve was used to evaluate the predictive value of blood lipids for reduced exercise tolerance in CHD patients.Results:Multivari-ate Logistic regression analysis showed that after adjusting for age,histories of smoking,drinking,hypertension,diabetes mellitus,myocardial infarction and post—percutaneous coronary intervention(PCI),HDL—C was an independent protec-tive factor for reduced exercise tolerance in CHD patients(OR=0.251,P=0.020).ROC curve analysis showed that the area under the ROC curve(AUC)of TG,HDL—C and vLDL—C was 0.591,0.663 and 0.587 respectively;the cut—off value was 1.83mmol/L,1.02mmol/L and 0.87mmol/L respectively,sensitivity was 44.09％,50.00％and 35.83％re-spectively,and the specificity was 79.07％,79.07％and 86.05％respectively in predicting reduced exercise tolerance in CHD patients.Conclusion:HDL—C serves as an independent protective factor of reduced exercise tolerance in CHD pa-tients,and can predict reduced exercise tolerance in CHD patients to a certain extent.
维普
万方数据
