Objective:To investigate the effects of prcoperative brain natriuretic peptide(BNP)level on the levels of inflammatory mediators in patients with acute ST segment elevation myocardial infarction(STEMI)after percutane-ous coronary intervention(PCI).Methods:The clinical data of 110 acute STEMI patients who underwent successful PCI in First People's Hospital of Fangchenggang City from January 2022 to January 2023 were retrospectively collect-ed.According to the median preoperative BNP level,they were divided into high BNP group(n=55)and low BNP group(n=55).The baseline data and related inflammatory indicators[C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),IL-10,IL-12,IL-37,IL-1β]and other laboratory indicators within 72h after PCI were further collected to analyze the relationship between preoperative BNP level and inflam-matory mediator levels after PCI in acute STEMI patients.Meanwhile,the systemic inflammation index(SII)was used to evaluate the inflammation state at 72h after PCI,and preoperative serum BNP level was compared among patients with different SII values.Preoperative serum BNP level was compared between patients with different prog-nosis.Results:Compared with low BNP group,there were significant rise in postoperative serum levels of CRP[(6.61±1.07)mg/L vs.(7.14±1.17)mg/L],TNF-α[(8.29±1.62)μg/L vs.(9.16±1.54)μg/L],IL-6[(14.19±2.33)pg/mlvs.(15.18±1.81)pg/ml],IL-10[(24.11±5.13)μg/ml vs.(26.34±4.81)μg/ml],IL-12[(45.50±4.37)ng/L vs.(48.19±4.60)ng/L],IL-37[(184.02±18.33)pg/mlvs.(195.33±18.94)pg/ml]and IL-1β[(62.09±5.47)ng/L vs.(64.73±6.58)ng/L]in high BNP group(P＜0.05 or＜0.01).Pear-son linear correlation test indicated that preoperative serum BNP level was significant positively correlated with ser-um levels of CRP,TNF-α,IL-6,IL-10,IL-12,IL-37 and IL-1β in STEMI patients after PCI(r=0.258～0.394,P＜0.01 all).Preoperative serum BNP level among different SII groups:low SII group＜medium SII group＜high SII group,P＜0.05 or＜0.01.Compared with good prognosis group,there was significant rise in preopera-tive serum BNP level[(112.84±8.36)pg/ml vs.(118.63±9.71)pg/ml]in poor prognosis group(P=0.014).Binary Logistic regression analysis suggested that preoperative serum BNP level was an independent risk factor for short-term poor prognosis in STEMI patients after PCI(OR=1.082,95％CI:1.014-1.155,P=0.018).Con-clusion:Preoperative serum BNP is associated with postoperative inflammatory mediator levels and short-term poor prognosis in acute STEMI patients.
维普
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