Objective:The purpose of this study is to explore whether nicorandil can reduce myocardial infarction size and improve microcirculation of patients with ST-segment elevation myocardial infarction(STEMI)undergoing primary percutaneous coronary intervention(PCI)quantitatively assessed by cardiac magnetic resonance perfusion imaging.Methods:A total of 144 STEMI patients who were proposed to primary PCI in Deyang People's Hospital from August 2018 to September 2020 were enrolled.Patients were randomly divided into control group(n=69,rou-tine treatment)and nicorandil group(n=75).Patients in the nicorandil group were orally given nicorandil 5mg be-fore entering catheter room,followed by 5mg,three times a day after PCI.On(7±2)d after PCI,cardiac mag-netic resonance(CMR)perfusion imaging was performed to evaluate myocardial infarction size,microcirculatory obstruction mass,left ventricular ejection fraction(LVEF)and myocardial rescue index etc.Results:CMR results indicated that compared with the control group,there were significant reductions in myocardial infarction size[(29.27±13.96)％vs.(24.70±12.29)％]and microcirculatory obstruction mass[(1.92±0.98)％vs.(1.48± 0.81)％]in the nicorandil group,P＜0.05 or＜0.01.There were no significant difference in LVEF and myocardi-al rescue index between two groups,which were higher in nicorandil group,P＞0.05 both.Conclusion:Early usage of nicorandil during the perioperative period of primary PCI can significantly reduce myocardial infarction size and improve microcirculation in STEM I patients.
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