Objective:To investigate the effect of β-receptor blockers on cardiopulmonary exercise capacity in pa-tients with tachyarrhythmia.Methods:A total of 92 patients,who visited Department of Cardiology,Affiliated Huadong Hospital of Fudan University from January 2021 to June 2023 and were diagnosed as tachyarrhythmia,were enrolled.According to β receptor blocker usage before cardiopulmonary exercise test(CPET)or not,they were divided into control group(n=45,didn't use β receptor blocker)and drug group(n=47,used metoprolol suc-cinate sustained-release tablet).The baseline data of the two groups were collected,and CPET indexes were com-pared between two groups.Results:Compared with the control group,there were significant reductions in resting heart rate[(78.73±11.46)beats/min vs.(73.72±11.21)beats/min],peak heart rate[(125.69±18.39)beats/min vs.(115.15±15.94)beats/min],peak oxygen uptake[(1.36±0.31)L/minvs.(1.21±0.26)L/min],peak oxygen uptake as a percentage of predicted[(75.38±15.73)％vs.(67.96±14.22)％],peak power[(104.73± 22.70)W vs.(94.98±20.57)W]and peak metabolic equivalent[(5.73±1.27)vs.(5.13±1.15)]in the drug group,P＜0.05 or＜0.01.Pearson correlation analysis indicated that there was a significant positive correlation be-tween peak oxygen uptake and peak heart rate in the drug group(r=0.453,P=0.001).Conclusion:β-receptor blockers can reduce cardiopulmonary exercise capacity in patients with tachyarrhythmia,which may be associated with the negative heart rate effects of β-receptor blockers.
关键词
心律失常,心性/肾上腺素能β受体拮抗剂/心肺运动试验
Key words
Arrhythmias,cardiac/Adrenergic beta-antagonists/Cardiopulmonary exercise test
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