Objective:To explore clinical effect of glucose-insulin-potassium(GIK)combined with low-dose do-pamine on heart failure with reduced ejection fraction(HFrEF).Methods:A total of 124 HFrEF patients treated in our hospital from Jan to Jun,2022 were enrolled,randomly divided into control group(n=60,basic therapy for heart failure)and treatment group(n=64,received GIK combined with low-dose dopamine intravenous drip based on routine treatment),both groups were treated for 5d.Levels of N terminal pro brain natriuretic peptide(NT-proBNP),serum creatinine(SCr),left ventricular ejection fraction(LVEF)and left ventricular end-diastolic di-ameter(LVEDd)before and after treatment,and incidence of adverse reactions during treatment were observed and compared between two groups.Results:Compared with control group after treatment,there were significant reductions in levels of NT-proBNP[(3690.68±1091.98)pg/ml vs.(2798.38±1112.07)pg/ml],SCr[(93.23 ±7.02)μmol/L vs.(77.90±6.75)μmol/L]and LVEDd[(54.57±2.06)mm vs.(53.83±1.80)mm],and sig-nificant rise in LVEF[(40.50±3.41)％vs.(41.89±3.39)％]in treatment group,P＜0.05 or＜0.01.The total incidence rate of adverse reactions in treatment group was significantly lower than that of control group(28.1％vs.55.0％,P=0.002).Conclusion:GIK combined with low-dose dopamine based on routine treatment can signifi-cantly improve left ventricular ejection fraction,reduce left ventricular end-diastolic diameter and protect kidney function in patients with heart failure with reduced ejection fraction,and the incidence rate of adverse reactions is low.
维普
万方数据