Objective:To investigate the diagnostic value of 6 min walking distance(6MWD)and N-terminal pro-brain natriuretic peptide(NT-proBNP)for heart failure with preserved ejection fraction(HFpEF).Methods:Clinical data of 80 HFpEF patients(HFpEF group)who admitted to Department of Cardiology,First Affiliated Hospital of Harbin Medi-cal University from January 2019 to April 2021,and 85 healthy subjects(healthy control group)who simultaneously re-ceived physical examination were retrospectively analyzed.General data,6MWD and plasma NT-proBNP level were com-pared between two groups,and the receiver operating characteristic curve(ROC)was used to evaluate the diagnostic value of 6MWD,plasma NT-proBNP and their combined detection for HFpEF.Results:Compared with healthy control group,there was significant rise in plasma NT-proBNP level[436.31(410.93,476.40)pg/ml vs.960.25(750.40,1460.50)pg/ml],and significant reduction in 6MWD[440.00(412.00,460.00)m vs.359.00(300.00,403.75)m]in HFpEF group,P=0.001 both.ROC curve analysis indicated that both plasma NT-proBNP and 6MWD possessed high diagnostic value for HFpEF(area under the curve(AUC)=0.935,0.821),and their cut-off values were 511.9pg/ml and 385.0m respectively,and AUC of combined detection(0.943)was higher than any single test,suggesting combined detection had higher diagnostic value.Conclusion:6min walking distance combined with plasma NT-proBNP detection possess high diagnostic value for HFpEF.
维普
万方数据