心血管康复医学杂志2024,Vol.33Issue(3) :285-289.DOI:10.3969/j.issn.1008-0074.2024.03.06

冠心病患者PCI术后β受体阻滞剂用药依从性下降的危险因素分析

Analysis of risk factors for decreased medication compliance of β receptor blocker in patients with coro-nary heart disease after PCI

侯晓鑫 郝俊霞 张晓敏
心血管康复医学杂志2024,Vol.33Issue(3) :285-289.DOI:10.3969/j.issn.1008-0074.2024.03.06

冠心病患者PCI术后β受体阻滞剂用药依从性下降的危险因素分析

Analysis of risk factors for decreased medication compliance of β receptor blocker in patients with coro-nary heart disease after PCI

侯晓鑫 1郝俊霞 1张晓敏1
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作者信息

  • 1. 河北北方学院附属第一医院心内科CCU,河北张家口 075000
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摘要

目的:研究冠心病(CHD)患者经皮冠状动脉介入(PCI)术后β受体阻滞剂用药依从性下降的危险因素.方法:选择2020年1月至2021年7月期间本院收治的160例行PCI治疗的CHD患者.术后根据Morisky用药依从性量表(MMAS-8)评分,≥6分者纳入高依从性组(100例),<6分者纳入低依从性组(60例).采用单因素和多因素Logistic回归分析CHD患者PCI术后β受体阻滞剂用药依从性降低的影响因素.结果:160例患者的平均MMAS-8评分为(5.81±0.12)分.与高依从性组比较,低依从性组年龄<60岁(74.00%比36.67%)、高中及以上(68.00%比40.00%)、支架植入<2年(54.00%比28.33%)比例、家庭关怀指数调查问卷(APGAR)评分[(5.12±1.60)分比(4.52±2.10)分]、APGAR评分≥7分比例(68.00%比33.33%)显著降低,家庭收入<3000 元(34.00%比 61.67%)、自费(36.00%比 60.00%)、糖尿病(47.00%比 66.67%)和高血压(42.00%比65.00%)比例显著升高,P<0.05或<0.01.多因素Logistic回归分析显示初中文化程度、年龄≥60岁、家庭收入<3000元、自费、支架植入时间≥2年、高血压、糖尿病是CHD患者PCI术后β受体阻滞剂用药依从性下降的独立危险因素(OR=8.445~97725.056,P<0.05或<0.01),而APGAR评分≥7分为其独立保护因素(OR=0.005,P=0.001).结论:CHD患者PCI术后的β受体阻滞剂用药依从性降低的影响因素包括年龄、支架植入时间、文化程度等,应该重点监督存在危险因素患者的用药情况并给予干预,有助于提升用药依从性.

Abstract

Objective:To investigate the risk factors of decreased medication compliance of β-receptor blocker in patients with coronary heart disease(CHD)after percutaneous coronary intervention(PCI).Methods:A total of 160 CHD patients undergoing PCI from January 2020 to July 2021 in our hospital were selected.According to post-operative Morisky medication adherence scale(MMAS-8)score,they were divided into high compliance group(n=100,≥6 points)and low compliance group(n=60,<6 points).Univariate and multivariate Logistic regression analysis were conducted to analyze the influencing factors of decreased medication compliance of β-receptor blocker in CHD patients after PCI.Results:The mean MMAS-8 score of 160 patients was(5.81±0.12)points.Com-pared with high compliance group,there were significant reductions in percentages of age<60 years(74.00%vs.36.67%),high school or higher education(68.00%vs.40.00%),stent implanted duration<2 years(54.00%vs.28.33%),family APGAR index score[(5.12±1.60)points vs.(4.52±2.10)points],proportion of APGAR score≥7 points(68.00%vs.33.33%),and significant rise in percentages of family income<3000 RMB(34.00%vs.61.67%),self-paying(36.00%vs.60.00%),diabetes(47.00%vs.66.67%)and hypertension(42.00%vs.65.00%)in low compliance group,P<0.05 or<0.01.Multivariate Logistic regression analysis indicated that junior high school education,age ≥60 years,family income<3000 RMB,self-paying,stent implanted duration≥2 years,hypertension and diabetes were independent risk factors for decreased medication compliance of β-re-ceptor blocker in CHD patients after PCI(OR=8.445~97725.056,P<0.05 or<0.01),while APGAR score ≥7 points was its independent protective factor(OR=0.005,P=0.001).Conclusion:The influencing factors for de-creased medication compliance of β-receptor blocker in CHD patients after PCI include age,stent implanted dura-tion,education level etc.It is necessary to focus on monitoring the medication of patients with risk factors and per-form intervention,which is helpful to improve medication compliance.

关键词

冠心病/血管成形术,气囊,冠状动脉/肾上腺素能β受体拮抗剂/服药依从性/危险因素

Key words

Coronary disease/Angioplasty,balloon,coronary/Adrenergic beta-antagonists/Medication adher-ence/Risk factors

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基金项目

河北省医学科学研究重点课题(2018)(20180866)

出版年

2024
心血管康复医学杂志
福建省康复医学会 中国康复医学会

心血管康复医学杂志

CSTPCD
影响因子:1.157
ISSN:1008-0074
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