Hypertrophic cardiomyopathy is an autosomal dominant disease,which can be divided into obstructive type and non-obstructive type.Hypertrophic obstructive cardiomyopathy is a common cause of sudden death in young people and athletes,and is also an important cause of sudden cardiac death.Currently,the treatment of hyper-trophic obstructive cardiomyopathy mainly includes drug therapy,surgical septal myectomy,interventional therapy and cardiac resynchronization therapy.This paper is the review of research progress of the comprehensive treatment of hypertrophic obstructive cardiomyopathy,in order to provide theoretical basis and reference for the selection of the treatment scheme of hypertrophic obstructive cardiomyopathy.