Acute ST-segment elevation myocardial infarction(STEMI)is one of the main causes of death and disa-bility in the East and the West.Though medical technology develops rapidly,its morbidity and mortality are still high.High mobility group box 1(HMGB1)is a kind of damage associated molecule patterns(DAMPs)that is re-leased from inflammatory cells and necrotic cells,causing inflammatory activation,releasing inflammatory factors,triggering the coagulation cascade,regulating cell migration,chemotaxis,apoptosis and autophagy.This review aims to describe the advances in the mechanism of HMGB1 involved in acute STEMI,and hope to provide new ideas for the prevention,treatment and prognosis improvement of STEMI.
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