Pulmonary embolism(PE)has become an important cause of sudden death in hospital.At present,serum D-dimer is often used in the exclusion diagnosis of PE in clinical practice.However,due to its poor specificity and influence of various factors,more convenient blood markers are still needed to improve the early diagnosis rate of PE and assist in risk stratification and management of PE patients.This article elaborates the research progress of the association of D-dimer and other representative blood biomarkers,including fibrinogen,neutrophil/lympho-cyte ratio(NLR),platelet/lymphocyte ratio(PLR),heart-related markers,molecular related markers with PE.This paper reviews the clinical value of PE-related biomarkers in blood,including their diagnostic and prognostic a-bilities.