Objective:To investigate association of expression levels of serum long non-coding RNA(lncRNA)myo-cardial infarction-associated transcript(lncRNA MIAT)and microRNA-150-5p(miR-150-5p)with coronary artery plaque in patients with coronary heart disease(CHD).Methods:A total of 260 CHD patients admitted in Hebei Petro China Central Hospital between October 2016 and January 2022 were selected.According to coronary angiography(CAG)results,they were divided into stable angina pectoris(SAP)group(n=97)and acute coronary syndrome(ACS)group(n=163),another 97 patients who were excluded for CHD by CAG simultaneously were re-garded as control group.Expression levels of serum lncRNA MIAT and miR-150-5p were measured in all groups;CHD patients received intravascular ultrasound(IVUS)examination,and coronary artery plaque related indexes were compared between SAP group and UAP group.Pearson method was used to analyze the association of expres-sion levels of serum lncRNA MIAT and miR-150-5p with coronary artery plaque related indexes in ACS patients.Results:Compared with control group,SAP group and ACS group had significant higher serum lncRNA MIAT ex-pression level,and significant lower miR-150-5p expression level(P＜0.001 all);compared with SAP group,ACS group had significant higher lncRNA MIAT expression level,vascular remodeling index,necrosis core(NC)area,plaque eccentricity index,and significant lower miR-150-5p expression level and fibrous fat fraction(FF)area(P＜0.001 all).Pearson correlation analysis indicated that in ACS patients,serum lncRNA MIAT expression level was positively correlated with vascular remodeling index,NC area and plaque eccentricity index(r=0.537,0.484,0.392,P＜0.001 all),and inversely correlated with FF area(r=-0.496,P＜0.001);miR-150-5p ex-pression level was inversely correlated with vascular remodeling index,NC area and plaque eccentricity index(r=-0.403,-0.584,-0.546,P＜0.001 all),and positively correlated with FF area(r=0.388,P＜0.001).Conclu-sion:The expression levels of serum lncRNA MIAT and miR-150-5p are abnormal in CHD patients.Expression levels of serum lncRNA MIAT and miR-150-5p are related to coronary artery plaques in ACS patients,which has important significance for clinical diagnosis,prevention and treatment.
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