Objective:This study aimed to investigate the clinical characteristics and related influencing factors of obese patients with obstructive sleep apnea syndrome(OSAS)and hypertension.Methods:A total of 201 obese OS-AS patients who admitted and were diagnosed in Tianyou Hospital Affiliated to Wuhan University of Science & Tech-nology between January 2020 and September 2022 were retrospectively selected,the 100 cases complicated with hy-pertension were treated as hypertension group and 101 cases without hypertension were regarded as control group.According to apnea hypopnea index(AHI),all obese OSAS patients were divided into mild OSAS group(n=36),moderate OSAS group(n=48)and severe OSAS group(n=117).General data,blood biochemical indexes,cardiac color ultrasound and polysomnography(PSG)indexes were collected in all groups.Correlation between blood pres-sure and OSAS-related indexes in obese OSAS patients was analyzed by Pearson correlation analysis.Multivariate Logistic regression was used to analyze influencing factors of hypertension in obese OSAS patients.Results:Com-pared with those in control group,patients in hypertension group had significant higher age,proportions of type 2 diabetes mellitus(T2DM),coronary heart disease and moderate OSAS,systolic blood pressure(SBP),diastolic blood pressure(DBP),lipoprotein a[Lp(a)],uric acid(UA),fasting plasma glucose(FPG),high sensitive C re-active protein(hsCRP),left atrial diameter(LAD)and lowest oxygen saturation(LSO2),and significant lower proportion of severe OSAS and AHI(P＜0.05 or＜0.01).Pearson correlation analysis indicated that SBP and DBP were inversely correlated with AHI in obese OSAS patients(r=-0.177,P=0.035;r=-0.189,P=0.024).Multivariate Logistic regression showed that age(OR=1.073,95％C1 1.017～1.133,P=0.010),T2DM(OR=2.752,95％CI 1.245～6.082,P=0.011),UA(OR=1.011,95％CI 1.001～1.021,P=0.031),SBP(OR=1.313,95％CI 1.168～1.475,P＜0.001)and DBP(OR=1.304,95％CI 1.154～1.474,P＜0.001)were independent risk factors for hypertension in obese OSAS patients.Conclusion:Age,T2DM,UA,SBP and DBP are independent risk factors for hypertension in obese OSAS patients.Clinical staff can early identify and treat hypertension by detecting above-mentioned indexes.
万方数据
维普
