AMI合并HF患者应用重组人脑利钠肽的治疗效果

Therapeutic effect of recombinant human brain natriuretic peptide on patients with acute myocardial infarction and heart failure

帅文欢 ¹邹静姝 ²汤勇¹

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作者信息

1. 自贡市第四人民医院心血管内科,四川自贡 643000
2. 自贡市第四人民医院内分泌科,四川自贡 643000
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摘要

目的:探究急性心肌梗死(AMI)合并心力衰竭(HF)患者应用重组人脑利钠肽(rhBNP)治疗的效果.方法:选择2021年1月 2022年1月期间自贡市第四人民医院收治的90例AMI并发HF患者,依据随机数字表法分为联合治疗组、对照组,各45例.对照组患者给予硝酸甘油治疗,联合治疗组在对照组基础上给予冻干rhB-NP 治疗,持续3d后,对比两组临床疗效,血清内皮素1(ET-1)、一氧化氮(NO)、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白Ⅰ(cTnⅠ)水平.结果:联合治疗组的总有效率显著高于对照组(86.67％比68.89％,P=0.043).治疗后,与对照组比较,联合治疗组 cTnⅠ[(27.33±8.34)μg/L 比(20.56±6.53)μg/L]、CK-MB[(47.76±7.54)U/L 比(25.56±5.45)U/L]和 ET-1[(77.33±8.34)ng/L 比(64.56±6.44)ng/L]水平均显著下降,NO[(46.76±7.54)μmol/L 比(52.56±5.45)μmol/L]水平显著升高(P均＜0.001).结论:AMI合并HF患者应用rhBNP治疗疗效显著,可以有效改善血管内皮功能以及心肌酶水平,值得临床推广.

Abstract

Objective:To investigate the therapeutic effect of recombinant human brain natriuretic peptide(rhBNP)on patients with acute myocardial infarction(AMI)and heart failure(HF).Methods:This randomized controlled study enrolled 90 AMI+HF patients admitted in Zigong Fourth People's Hospital between January 2021 and Januar-y 2022.They were divided into control group(n=45,nitroglycerin therapy)and combined treatment group(n=45,lyophilized rhBNP therapy based on control group).After 3d continuous treatment,clinical therapeutic effect,serum levels of endothelin(ET)-1,nitric oxide(NO),creatine kinase isoenzyme MB(CK-MB)and cardiac tro-ponin Ⅰ(cTnⅠ)were compared between two groups.Results:Total effective rate of combined treatment group was significantly higher than that of control group(86.67％vs.68.89％,P=0.043).Compared with patients in con-trol group after treatment,those in combined treatment group had significant lower levels of cTnⅠ[(27.33±8.34)μg/L vs.(20.56±6.53)μg/L],CK-MB[(47.76±7.54)U/L vs.(25.56±5.45)U/L]and ET-1[(77.33±8.34)ng/L vs.(64.56±6.44)ng/L],and significant higher NO level[(46.76±7.54)μmol/L vs.(52.56±5.45)μmol/L](P＜0.001 all).Conclusion:rhBNP has significant therapeutic effect on AMI+HF patients,it may effec-tively improve vascular endothelial function and myocardial enzyme level,which is worthy of clinical promotion.

关键词

心肌梗死/心力衰竭/冻干重组人脑利钠肽

Key words

Myocardial infarction/Heart failure/Lyophilized recombinant human brain natriuretic peptide

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出版年

2024

心血管康复医学杂志

福建省康复医学会中国康复医学会

心血管康复医学杂志

CSTPCD

影响因子：1.157

ISSN：1008-0074

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