Objective:This study aims to investigate the influence of left bundle branch area pacing(LBBAP)on left ventricular systolic synchronization and prognosis in patients with chronic systolic heart failure.Methods:According to different pacing methods,a total of 110 patients with chronic systolic heart failure admitted in Maanshan General Hospital of Ranger-Duree Healthcare between June 2020 and December 2021 were divided into LBBAP group(n=60)and right ventricular pacing(RVP)group(n=50).Pacing parameters,cardiac function,left ventricular systol-ic synchronization related indexes before and 3 months after operation,and prognosis after 6 months were compared between two groups.Results:Compared with patients in RVP group 3 months after operation,those in LBBAP group had significant lower pacing impedance[(560.34±61.32)Ω vs.(507.20±44.29)Ω],QRS duration[(132.57±22.91)ms vs.(123.61±20.55)ms],peak strain dispersion(PSD)[(58.24±10.57)ms vs.(45.30±6.20)ms],time to longitudinal systolic strain difference(Tls-Dif)[(238.57±50.13)ms vs.(152.42±40.15)ms],transverse systolic strain difference(Trs-SD)[(122.35±9.14)ms vs.(78.18±5.46)ms]and time to aor-tic systolic strain posterior(Tas-post)[(138.19±20.36)ms vs.(69.14±20.45)ms],and significant higher left ventricular ejection fraction(LVEF)[(46.62±5.80)％vs.(50.54±5.68)％](P＜0.05 or＜0.01).Proportion of positive response to cardiac resynchronization therapy(CRT)after 6 months in LBBAP group was significantly higher than that of RVP group(88.33％vs.72.00％,P=0.030).There were no significant difference in heart failure-caused rehospitalization rate and all-cause mortality between two groups(P＞0.05 both).Conclusion:LB-BAP could effectively improve cardiac function,ensure the synchronization of left ventricular contraction,with high CRT response rate and good prognosis in patients with chronic systolic heart failure.
维普
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