The influence of using penetrating protective agents at different ages on the antifouling ability and surface morphol-ogy of cement-based inorganic artificial stones was studied through testing methods such as color difference,microstructure,and high-throughput CT in antifouling tests.The results showed that the use of penetrating protective agents during the hydration pro-cess of cement-based inorganic artificial stones had the best hydration age window.Spraying penetrating protective agents within 24 h to 72 h improved the resistance of cement-based inorganic artificial stones to methyl violet pollution by 41.7%,while spraying penetrating protective agents within 7~24 h increased the resistance of cement-based inorganic artificial stones to vinegar pollution by 33.0%.The anti-pollution ability of cement-based artificial stone can be effectively improved by spraying penetrant during the best window period of 7~72 h.