Objective To investigate the expression of proliferating cell nuclear antigen (PCNA) and N-myc downstream regulated gene 1 (NDRG1) in breast carcinoma tissues.Methods Ninety specimens of breast resection surgery were sliced.The protein expression of PCNA and NDRG1 in 45 breast carcinoma tissues,23 benign breast lesions tissues and 22 specimens of normal tissue adjacent the breast carcinoma were examined by immunohistochemical strept avidin-biotin complex (SABC) method.The relationship of the protein expression of PCNA and NDRG1 with the biological behavior of breast carcinoma was analyzed.Results The expression rates of PCNA in breast carcinoma tissues,benign breast lesions tissues and normal tissue adjacent the breast carcinoma were 36.3％,62.5％ and 88.9％ respectively.The expression of PCNA in the normal tissues adjacent breast carcinoma was significantly lower than that in the mammary gland hyperplasia tissue and breast carcinoma tissues(P ＜ 0.05).The expression rates of NDRG1 in breast carcinoma tissues,benign breast lesions tissues and normal tissue adjacent the breast carcinoma were 63.6％,30.4％ and 15.5％ respectively.The expression of NDRG1 in the normal tissues adjacent breast carcinoma was significantly higher than that in the mammary gland hyperplasia tissue and breast carcinoma tissues (P ＜ 0.05).The expressions of PCNA was negatively correlated with the expression of NDRG1 (r =-0.679,P ＜0.05).Conclusion Interaction between PCNA and NDRG1 may be related the carcinogenesis of breast carcinoma.Combination detection of PCNA and NDRG1 proteins may contribute to the judgment of malignant degree of the breast carcinoma.
breast cancerproliferating cell nuclear antigenN-myc downstream regulated gene 1
NETL
NSTL
万方数据
维普
