摘要
股骨头坏死(ONFH)是骨科常见且难治的疾病,其发生与脂质代谢紊乱、内皮功能障碍、骨稳态失衡和基因多态性等多种因素有关,但其具体机制尚未完全阐明.ONFH早期进展隐匿,发展到后期往往需要进行人工髋关节置换术,给患者及社会带来沉重的经济负担.非编码RNA是近年来医学研究的热点,越来越多的非编码RNA被发现能够通过多种机制调控ONFH的发生和发展.本文就非编码RNA在ONFH发生、发展和治疗中的作用研究进展进行综述,以期为ONFH的治疗提供参考.
Abstract
Osteonecrosis of the femoral head(ONFH)is a common and intractable disease in orthopedics,and its occurrence is associated with lipid metabolism disorders,endothelial dysfunction,bone homeostasis imbalance,genetic polymorphism,etc.However,the specific mechanism has not been fully elucidated.ONFH has an insidious progression in the early stages,and in the later stages,it often requires hip replacement surgery,which imposes a heavy economic burden on patients and society.Non-coding RNA has been the hotspot of medical research in recent years,and increasing number of non-coding RNA has been found to regulate the occurrence and development of ONFH through various mechanisms.This article reviews the research progress on the role of non-coding RNA in the occurence,development and treatment of ONFH,in order to provide reference for the treatment of ONFH.
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