Currently,methamphetamine(MA)has become the most commonly abused synthetic stimulant.The long-term use of MA has resulted in serious mental disorders and cognitive impairments,posing significant public health and social issues both domestically and internationally.As a novel adjunctive therapy,exercise intervention can effectively mitigate the neuro-structural and functional injury caused by MA by suppressing neural oxidative stress,reducing inflammatory factors and cellular apoptosis levels,restoring glutamate/gamma-aminobutyric acid homeostasis and blood-brain barrier function,and promoting neuroplasticity.Exercise intervention also contributes to decreasing drug cravings,enhancing physical fitness,alleviating with-drawal symptoms,and reducing negative subjective emotions among addicts.Therefore,scientifically tailored exercise interven-tion programs with abundant types of sports and personalized exercise programs designed based on the physical and mental conditions of individuals with addiction can lead to better intervention outcomes and reduce the risk of relapse.This paper provides a comprehensive review of the research progress on the effects,mechanisms and intervention strategies of exercise on neural injury in MA addicts,aiming to provide evidence for the application of exercise intervention in drug withdrawal programs for MA addicts.
维普
万方数据
