新乡医学院学报2024,Vol.41Issue(2) :197-200.DOI:10.7683/xxyxyxb.2024.02.017

肿瘤干细胞生物标志物在宫颈癌进展及治疗中的作用研究进展

Research progress on the role of cancer stem cell biomarkers in the progression and treatment of cervical cancer

李珂 王倩青
新乡医学院学报2024,Vol.41Issue(2) :197-200.DOI:10.7683/xxyxyxb.2024.02.017

肿瘤干细胞生物标志物在宫颈癌进展及治疗中的作用研究进展

Research progress on the role of cancer stem cell biomarkers in the progression and treatment of cervical cancer

李珂 1王倩青2
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作者信息

  • 1. 新乡医学院第四临床学院,河南 新乡 453000
  • 2. 新乡市中心医院妇科妇瘤科,河南 新乡 453000
  • 折叠

摘要

肿瘤干细胞(CSCs)是启动癌症的一个细胞亚群,其与化学治疗耐药和癌症复发有关.宫颈癌是威胁全球女性健康的主要恶性肿瘤之一.随着宫颈癌筛查的普及,部分早期宫颈癌及癌前病变得到发现和治疗,但中晚期宫颈癌的治疗及预后并未得到明显改善,治疗方式仍以手术和放化疗为主.因此,针对宫颈癌CSCs的有效靶向策略对于监测宫颈癌治疗进展和评估新型治疗方法的重要性日益凸显.本文就宫颈癌CSCs生物标志物在宫颈癌进展中的作用及其作为治疗靶点的潜力作一简要综述.

Abstract

Cancer stem cells(CSCs)are a small subgroup of cells capable of initiating cancer and are associated with chemotherapy resistance and cancer recurrence.Cervical cancer is one of the major malignant tumors threatening women's health worldwide.With the popularization of cervical cancer screening,some early cervical cancer and precancerous lesions have been discovered and timely treated,but the treatment and prognosis of mid-to late-stage cervical cancer have not been markedly improved.The treatments of mid-to late-stage cervical cancer are still surgery,radiotherapy and chemotherapy.There-fore,effective targeting strategies for cervical cancer CSCs are increasingly important for monitoring the progress of cervical cancer treatment and evaluating new treatment methods.This article provides a brief review of the role of biomarkers of cervical cancer CSCs in the progression of cervical cancer and their potential as therapeutic targets.

关键词

宫颈癌/肿瘤干细胞/标志物/靶向治疗

Key words

cervical cancer/cancer stem cells/biomarkers/targeted therapy

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基金项目

河南省科技攻关项目(222102520012)

出版年

2024
新乡医学院学报
新乡医学院

新乡医学院学报

CSTPCD
影响因子:0.999
ISSN:1004-7239
参考文献量43
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