Contactin-1(CNTN1)is a neural cell adhesion molecule belonging to the subgroup of immunoglobulin superfamily.It is anchored on the cell surface through glycosyl phosphatidyl inositol-anchored neural membrane proteins and participates in axon guidance,synapse formation,growth and development of nervous systems,and occurrence of related disea-ses.In addition,CNTN1 can promote inflammatory response and signal communication between microglia and astrocytes through various mechanisms,playing a role in the pathological processes of various neurological and psychiatric disorders.This article discusses the role of CNTN1 in depression and cognitive dysfunction.
维普
万方数据
