The pathogenesis of aplastic anemia(AA)is complex and associated with hematopoietic stem cell defect,abnormal bone marrow microenvironment,immune dysfunction,and somatic mutation,in which the immune mechanism plays an important role.This article reviews the pathogenesis of AA from the following aspects:regulatory T cell reduction,hematopoietic stem cell reduction caused by factor-related apoptosis/factor-related apoptosis ligand signaling pathway,aberrant target gene expression induced by inflammatory factor-stimulated microRNAs,and regulatory T cell dysfunction,so as to provide ideas and methods for clinical practice.
关键词
再生障碍性贫血/调节性T细胞/凋亡相关因子/凋亡相关因子配体信号通路/微RNAs
Key words
aplastic anemia/regulatory T cell/factor-related apoptosis/factor-related apoptosis ligand signaling pathway/microRNAs
维普
万方数据