Objective To investigate the clinical effect of esketamine on anesthesia induction in total hip replacement.Methods A total of 60 patients undergoing total hip replacement under general anesthesia in the First Affiliated Hospital of Xinxiang Medical University from October 2021 to June 2022 were selected as the research subjects.According to the random number table method,the patients were divided into the control group and the observation group,with 30 patients in each group.Patients in the observation group were given esketamine(0.5 mg·kg-1)during anesthesia induction,patients in the control group were given placebo,and other induction drugs and intraoperative maintenance drugs used in the two groups were the same.The heart rate(HR),mean arterial pressure(MAP)and blood oxygen saturation(SpO2)were recorded and compared between the two groups after entry into the operating room(T0),after anesthesia induction(T1),after endotracheal intubation(T2),and at skin suturing(T3).The anesthesia recovery time and post-anesthesia care unit(PACU)residence time of patients in the two groups were recorded and compared.The sedation and pain levels of patients were evaluated by the Ramasy sedation scale(RSS)and numerical rating scale(NRS)at 2,6,12,and 24 hours after operation.The incidence of adverse reactions,such as postoperative agitation,nausea and vomiting,and respiratory depression,was compared between the two groups.Results No significant difference was found in HR and MAP between the two groups at T0,T2 and T3(P＞0.05).HR and MAP of patients in the observation group at T,were significantly higher than those in the control group(P＜0.05).There was no significant difference in SpO2 between the two groups at T0,T1,T2 and T3(P＞0.05).There was no significant difference in PACU residence time between the two groups(P＞0.05).The anesthesia recovery time of patients in the observation group was significantly shorter than that in the control group(P＜0.05).The RSS score of patients in the observation group was significantly higher than that in the control group at 2 hours after surgery,but the NRS score of patients in the observation group was significantly lower than that in the control group at 2 hours after surgery(P＜0.05).There was no significant difference in RSS and NRS scores between the two groups at 6,12 and 24 hours after surgery(P＞0.05).The incidence of postoperative adverse reactions in the control and observation groups was 13.3％(4/30)and 6.7％(2/30),respectively.There was no significant difference in the incidence of postoperative adverse reactions between the two groups(x2=0.741,P＞0.05).Conclusion Esketamine can reduce the pain after total hip replacement,shorten the time to recovery from anesthesia,and make hemodynamics more stable,showing higher safety.
esketaminetotal hip replacementanesthesia induction
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