Objective To explore the correlation between liver and kidney function and serum testosterone in neonatal children with congenital adrenal hyperplasia(CAH).Methods A total of 38 CAH neonates admitted to the Children's Hospital Affiliated to Zhengzhou University from January 2019 to June 2022 were selected as the observation group.Another 38 healthy newborns in this hospital during the same period were selected as the control group.Liver and kidney function indexes of neonates in the two groups were compared,including serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),total protein(TP),albumin(ALB),globulin(GLB)and γ-glutamyltranspeptidase(GGT),serum creatinine(Scr),uric acid(UA),blood urea nitrogen(BUN)levels,and the correlation between each index and testosterone were analyzed.Results There was no statistically significant differences in gender,age,birth weight,body temperature,pulse,blood pressure and serum ALT,AST and ALP levels of neonates between the observation group and control group(P＞0.05),while there were statistically significant differences in serum testosterone,TP,ALB,GLB,GGT,Scr,UA and BUN of neonates between the observation group and control group(P＜0.05).Correlation analysis showed that the levels of TP,ALB,GLB,Scr,UA and BUN were positively correlated with testosterone(r=0.604,0.519,0.465,0.523,0.434,0.510;P＜0.05).Conclusion TP,ALB,GLB,Scr,UA and BUN are positively correlated with testosterone levels in CAH neonates.With the increase in serum testosterone levels,liver secretion function is enhanced,and the degree of renal impairment is aggravated.
newborncongenital adrenal hyperplasialiver and kidney functiontestosterone
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