摘要
目的 探讨先天性肾上腺皮质增生症(CAH)新生儿血清睾酮与肝肾功能的相关性.方法 选择2019年1月至2022年6月郑州大学附属儿童医院收治的38例CAH新生儿作为观察组;另选择同期本院体检健康新生儿38例作为对照组.比较2组新生儿肝肾功能指标血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、碱性磷酸酶(ALP)、总蛋白(TP)、白蛋白(ALB)、球蛋白(GLB)、γ-谷氨酰转肽酶(GGT)、肌酐(Scr)、尿酸(UA)、血尿素氮(BUN)水平,并分析各指标与睾酮的相关性.结果 观察组与对照组新生儿的性别、年龄、出生体质量、体温、脉搏、血压和血清ALT、AST、ALP水平比较差异均无统计学意义(P＞0.05);观察组与对照组新生儿血清睾酮、TP、ALB、GLB、GGT、Scr、UA、BUN水平比较差异均有统计学意义(P＜0.05).相关性分析结果显示,TP、ALB、GLB、Scr、UA、BUN 水平与睾酮呈正相关(r=0.604、0.519、0.456、0.523、0.434、0.510,P＜0.05).结论 CAH 新生儿 TP、ALB、GLB、Scr、UA、BUN与睾酮水平呈正相关,随着血清睾酮水平增加,肝分泌功能增强,肾功能损伤程度加重.
Abstract
Objective To explore the correlation between liver and kidney function and serum testosterone in neonatal children with congenital adrenal hyperplasia(CAH).Methods A total of 38 CAH neonates admitted to the Children's Hospital Affiliated to Zhengzhou University from January 2019 to June 2022 were selected as the observation group.Another 38 healthy newborns in this hospital during the same period were selected as the control group.Liver and kidney function indexes of neonates in the two groups were compared,including serum alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),total protein(TP),albumin(ALB),globulin(GLB)and γ-glutamyltranspeptidase(GGT),serum creatinine(Scr),uric acid(UA),blood urea nitrogen(BUN)levels,and the correlation between each index and testosterone were analyzed.Results There was no statistically significant differences in gender,age,birth weight,body temperature,pulse,blood pressure and serum ALT,AST and ALP levels of neonates between the observation group and control group(P＞0.05),while there were statistically significant differences in serum testosterone,TP,ALB,GLB,GGT,Scr,UA and BUN of neonates between the observation group and control group(P＜0.05).Correlation analysis showed that the levels of TP,ALB,GLB,Scr,UA and BUN were positively correlated with testosterone(r=0.604,0.519,0.465,0.523,0.434,0.510;P＜0.05).Conclusion TP,ALB,GLB,Scr,UA and BUN are positively correlated with testosterone levels in CAH neonates.With the increase in serum testosterone levels,liver secretion function is enhanced,and the degree of renal impairment is aggravated.
基金项目
河南省医学科技攻关计划(LHGJ20200669)
NETL
NSTL
万方数据