Mild cognitive impairment(MCI)is a cognitive impairment syndrome that occurs from normal aging to dementia.In recent years,the incidence of cognitive impairment in the elderly has become higher and higher,which has become a serious problem for the elderly in today's society.Studies suggest that gut microbiota(GM)plays an important role in the development of MCI,which can affect the brain's action and cognitive ability,and then promote the occurrence and development of MCI.In addition,gut microbiota is also associated with different types of MCI.Therefore,this paper reviews the influence of gut microbiota in the occurrence and development of MCI from four aspects:the correlation between cognitive decline and intestinal dysbacteriosis,the relationship between different types of mild cognitive impairment and intestinal dysbacteriosis,the relevant mechanism of gut microbiota affecting mild cognitive impairment,and the intervention of traditional Chinese medicine in impro-ving cognitive impairment of gut microbiota,and analyzes whether gut microbiota can become a new target for the prevention and treatment of MCI,in order to bring inspiration for the clinical prevention and treatment of mild cognitive impairment.
mild cognitive impairmentgut microbiotabrain-gut axisChinese medicinemechanisms of action
NETL
NSTL
万方数据
