Parkinson's disease(PD)is a protein conformational disease.Alpha-synuclein(ASN)in the physiological state is a disordered monomer,and ASN in the pathological state is in an aggregated state.The pathological spread of ASN along the neuraxis is closely related to the clinical manifestations of PD.Pathogenic forms of ASN evoke oxidative stress,while neuroinflammation and protein alterations in neighboring cells intensify ASN toxicity,and result in neurodegeneration and neuronal death.Studies have also shown ASN is a key player in lipid metabolism regulation,dopamine production,and infla-mmatory responses by the binding and attraction to negatively charged lipids,and participates in the occurrence and development of PD.Abnormal lipid metabolism such as fatty acids,glycerides,and phospholipids is closely related to ASN aggregation.Therefore,abnormal lipid metabolism plays an important role in the occurrence and development of PD.This article mainly reviews the research progress on the role and mechanism of lipids in the occurrence and development of PD,to provide references for research on PD prevention and treatment measures.
NETL
NSTL
万方数据
