Objective To investigate the effect of hyperbaric oxygen(HO)combined with ginkgo biloba extract(GBE)in elderly patients with vascular dementia.Methods A total of 132 elderly patients with vascular dementia who visited the Ninth People's Hospital of Zhengzhou from January 2019 to December 2022 were selected as the research subjects,and they were divided into the observation group and control group using a random number table method,with 66 patients in each group.Both groups of patients received routine treatment,while the control group received HO therapy once a day;patients in the observation group were treated with HO combined with GBE once a day;both groups of patients were treated continuously for one month.The cognitive function and activities of daily living of two groups of patients before and after treatment were evaluated using the Montreal Cognitive Assessment(MoCA)scale and Barthel index,and the clinical efficacy of the two groups of patients after treatment was evaluated based on the MoCA score and Barthel Index.Transcranial Doppler ultrasound was used to detect the average blood flow velocity(ABFV)of the anterior cerebral artery(ACA),posterior cerebral artery(PCA),middle cerebral artery(MCA)and vertebral artery(VA)in the two groups of patients before and after treatment.Results There was no statistically significant difference in MoCA score and Barthel index between the two groups of patients before treatment(P＞0.05).After treatment,the MoCA score and Barthel index of both groups of patients were higher than those before treatment(P＜0.05),and the MoCA score and Barthel index in the observation group were higher than those in the control group(P＜0.05).After treatment,the total effective rates of the control group and the observation group were 84.85％(56/66)and 95.45％(63/66),respectively,and the total effective rate of the observation group was significantly higher than that of the control group(x2=4.181,P＜0.05).There was no statistically significant difference in the ABFV of the ACA,PCA,MCA and VA between the two groups of patients before treatment(P＞0.05).After treatment,the ABFV of the ACA,PCA,MCA and VA in the two groups of patients was higher than that before treatment(P＜0.05),and the observation group was higher than the control group(P＜0.05)in terms of the ABFV of the ACA,PCA,MCA and VA.The total incidence of adverse reactions in the control group and observation group during treatment was 16.67％(11/66)and 18.18％(12/66),respectively,and there was no statistically significant difference in the total incidence of adverse reactions between the two groups of patients(x2=0.218,P＞0.05).Conclusion The combination of HO and GBE can significantly improve cerebral blood flow status and cognitive dysfunction in patients with vascular dementia and enhance their activities of daily living with good overall efficacy and high safety.
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