Pathogenic bacteria distribution and drug resistance analysis of urinary tract infection after laparo-scopic radical prostatectomy in elderly patients with early prostate cancer
Objective To analyze the distribution and drug resistance of pathogens causing urinary tract infections in elderly patients with early prostate cancer after laparoscopic radical prostatectomy.Methods Totally 148 elderly early-stage prostate cancer patients who underwent laparoscopic radical prostatectomy at Tongxu First Hospital from January 2021 to October 2023 and developed urinary tract infections were selected as the research subjects.After confirming the occurrence of urinary tract infections,the patients underwent mid-stream urine pathogen culture and identification and drug susceptibility testing.The medical records were checked and the results of the culture and identification of pathogenic bacteria and drug sus-ceptibility testing of the main pathogenic bacteria were recorded.Results A total of 156 strains of pathogenic bacteria were collected from 148 patients with urinary tract infections.There were 8 strains of fungi(5.13％),50 strains of Gram-positive bacteria(32.05％)and 98 strains of Gram-negative bacteria(62.82％).Among the 8 fungi strains,6 were Canidia albicans(75.00％)and 2 were other fungi(25.00％).Among the 50 Gram-positive bacteria,23 were Enterococcus faecalis(46.00％),11 were Staphylococcus aureus(22.00％),9 were Enterococcus faecium(18.00％),and 7 were Staphylococcus epidermidis(14.00％).Among the 98 strains of Gram-negative bacteria,56 strains were Escherichia coli(57.14％),20 strains were Klebsiella pneumoniae(20.41％),8 strains were Acinetobacter baumannii(8.16％),8 strains were Enterobacter cloacae(8.16％),and 6 strains were Pseudomonas aeruginosa(6.12％).The resistance rate of Escherichia coli to ampicillin,ampicillin/sulbactam,cefazolin and ceftriaxone was relatively high(57.14％-80.36％),while the resistance rate to meropenem,imipenem,amikacin,tigecycline and furantoin was relatively low(1.79％-3.57％).Klebsiella pneumoniae had a high resistance rate(55.00％-80.00％)to ampicillin,azithromycin,ampicillin/sulbactam,ceftriaxone and cefazolin,while a low resistance rate(5.00％-10.00％)to gentamicin,amikacin and tigecycline.The resistance rate of Enterococcus faecalis to gentamicin,penicillin G,ciprofloxacin,erythromycin,levofloxacin and linezolid was relatively high(47.83％-91.30％),while the resistance rate to vancomycin,teicoplanin and furantoin was relatively low(4.35％-8.70％).The resistance rates of Staphylococcus aureus to penicillin,erythromycin,streptomycin and ampicillin were high(81.82％-100.00％),and its resistance rates to vancomycin,linezolid,teicoplanin and nitrofurantoin were low(0.00％-9.09％).Conclusion Urinary tract infections in elderly early-stage prostate cancer patients after laparoscopic radical prostatectomy are mainly caused by Gram-negative bacteria.For clinical treatment,drug susceptibility testing results and the patient's situation should be considered to choosing a reasonable antimicrobial therapeutic scheme.
early prostate cancerlaparoscopic radical surgeryurinary tract infectionpathogenic bacteriadrug resistance
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