Objective To investigate the clinical efficacy of low tidal volume mechanical ventilation combined with human immunoglobulin in the treatment of severe pneumonia in children and the effects on lung function and humoral immune function.Methods A total of 126 children with severe pneumonia admitted to the Zhumadian Central Hospital from January 2019 to December 2020 were selected as the research subjects.According to the treatment method,the children were divided into a control group(n=65)and an observation group(n=61).All children in the two groups were given routine treatment.On this basis,children in the control group were given low tidal volume mechanical ventilation,while children in the observation group were given low tidal volume mechanical ventilation combined with human immunoglobulin.All children in the two groups were treated continuously for 1 week.The clinical efficacy,pulmonary function indexes[forced expiratory volume in one second(FEV1),forced vital capacity(FVC),and peak expiratory flow(PEF)]before and after treatment,blood gas analysis indexes[arterial partial pressure of oxygen(PaO2),arterial partial pressure of carbon dioxide(PaCO2),and oxygenation index(PaO2/FiO2)],humoral immune function indexes[immunoglobulin(Ig)A,IgG,and IgM],and the occurrence of adverse reactions were compared between the two groups.Results The total effective rates of children in the control group and the observation group were 73.85％(48/65)and 88.52％(54/61),respectively,and the total effective rate of children in the observation group was significantly higher than that in the control group(P＜0.05).There was no significant difference in FEV1,FVC and PEF between the two groups before treatment(P＞0.05).After treatment,FEV1,FVC and PEF of children in the two groups were significantly higher than those before treatment(P＜0.05).After treatment,FEV1,FVC and PEF of children in the observation group were significantly higher than those in the control group(P＜0.05).There was no significant difference in PaO2,PaCO2,and PaO2/FiO2 between the two groups before treatment(P＞0.05).After treatment,PaO2 and PaO2/FiO2of children in the two groups were significantly higher than those before treatment,while PaCO2 was significantly lower than that before treatment(P＜0.05).After treatment,PaO2 and PaO2/FiO2of children in the observation group were significantly higher than those in the control group,while PaCO2 was significantly lower than that in the control group(P＜0.05).There was no significant difference in IgA,IgG and IgM levels between the two groups before treatment(P＞0.05).After treatment,the IgA,IgG and IgM levels of children in the two groups were significantly lower than those before treatment(P＜0.05).After treatment,the IgA,IgG and IgM levels of children in the observation group were significantly lower than those in the control group(P＜0.05).The incidence of adverse reactions in the control group and the observation group was 18.46％(12/65)and 32.79％(20/61),respectively.There was no significant difference in the incidence of adverse reactions between the two groups(x2=0.007,P＞0.05).Conclusion Compared with low tidal volume mechanical ventilation,low tidal volume mechanical ventilation combined with human immunoglobulin has more significant clinical efficacy in the treatment of children with severe pneumonia,which can effectively improve lung function,blood gas analysis indexes and humoral immune function of children and will not significantly increase adverse reactions.
severe pneumoniasmall tidal volume mechanical ventilationhuman immunoglobulinlung functionhu-moral immunitychildren
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