Rehmannia glutinosa,belonging to the genus Rehmannia(family Scrophulariaceae),is a widely used Chinese medical herb that is included in the list of medicine and food homology substances in China.First described in Shennong's Classic of Materia Medica,it has been widely used clinically now.Mainly produced in Henan,Hebei,Shandong and Shanxi,the Rehmannia glutinosa in Huaiqing Prefecture(an ancient administrative district)of Henan is the most authentic,and it is listed as one of the four famous Chinese herbs produced in the Huaiqing area.In recent years,with the comprehensive and in-depth study of Rehmannia glutinosa by scholars at home and abroad,its diverse chemical constituents,extensive pharmacological actions,development and application have attracted much attention.In this paper,the relevant literature on the main chemical constituents and pharmacological activities of Rehmannia glutinosa is reviewed,in order to provide references for related research.