Chronic obstructive pulmonary disease(COPD)is a disease characterized by persistent respiratory symptoms and airflow limitation,and also associated with a variety of comorbidities.As one of the important extrapulmonary comorbidities of COPD,kidney injury has a high incidence and insidious onset,which will develop into chronic kidney disease without timely intervention,greatly increasing the risk of mortality and economic burden of COPD patients.There exist physiological and pathological relations between lung and kidney functions.However,the mechanisms underlying COPD-associated kidney injury remain unclear.This article provides a review of the research progress on the mechanisms of COPD-associated kidney injury,in order to provide reference for the clinical prevention and treatment and basic research.
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