Objective To explore the correlation between serum adiponectin(ADPN)and glucose and lipid metabolism in hemodialysis patients with diabetic nephropathy(DN).Methods A total of 96 DN patients who underwent hemodialysis at the First People's Hospital of Zhengzhou from January 2018 to January 2021 were selected as the research subjects(observation group),and 68 healthy subjects who came to the hospital for physical examination during the same period were selected as the control group.About 3 mL of fasting venous blood was collected from patients in the observation group before treatment and from subjects in the control group on the day of the physical examination.The serum was obtained by centrifugation,and the serum ADPN level was detected by using the enzyme-linked immunosorbent assay;the levels of total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)and triglyceride(TG)were measured by using a fully automatic biochemical analyzer;the fasting blood glucose(FBG)level was detected by using the glucose oxidase method;the glycosylated hemoglobin(HbA1c)level was detected by using the high-performance liquid chromatography;the fasting insulin(FINS)level was measured by using a fully automatic chemiluminescence apparatus.The correlation between serum ADPN levels and glucose and lipid metabolism in DN patients undergoing hemodialysis was analyzed by Pearson correlation.Results The serum ADPN level of patients in the observation group was significantly higher than that in the control group(t=14.392,P＜0.05).There was no statistically significant difference in TC and LDL-C levels of subjects between the two groups(P＞0.05).The serum HDL-C level of patients in the observation group was significantly lower than that in the control group,while the TG,FBG,HbA1c and FINS levels were significantly higher than those in the control group(P＜0.05).Pearson correlation analysis showed that serum ADPN in DN patients undergoing hemodialysis was positively correlated with HDL-C(r=0.563,P＜0.05)and negatively correlated with FBG,FINS and TG(r=-0.572,-0.610,-0.622;P＜0.05),but showed no corr-elation with TC,LDL-C and HbA1c(r=0.059,0.151,-0.038;P＞0.05).Conclusion The serum ADPN level of DN patients during hemodialysis is significantly higher than that of healthy people,which is related to abnormal glucose and lipid metabo-lism,and has certain significance for clinical judgment of the glucose and lipid metabolism status of DN patients receiving he-modialysis.
diabetic nephropathyhemodialysisadiponectinglucose and lipid metabolism
维普
万方数据
