Objective To explore the impact of Yupingfeng granules combined with glucocorticoids on airway function in children with cough variant asthma(CVA).Methods Eighty-three children with CVA admitted to the Department of Pediatrics of Xi'an Gaoxin Hospital from June 2020 to June 2023 were selected as the research subjects.The children were divided into control group(n=42)and observation group(n=41)according to the lottery method.Children in the control group were given glucocorticoid inhalation treatment,while children in the observation group were given Yupingfeng granules additionally on the basis of treatment in the control group.Clinical outcomes,inflammatory factor levels,airway function,lymphocyte subsets,and childhood asthma control test(C-ACT)scores of patients between the two groups were compared.The levels of tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),and interleukin-6(IL-6)were measured by using the double-antibody sandwich enzyme-linked immunosorbent assay before and after the treatment,respectively.The peak expiratory flow predicted(PEFpred),peak expiratory flow(PEF),percentage of forced expiratory volume in one second in predicted value(FEV,％pred),and forced expiratory volume in one second/forced vital capacity(FEV1/FVC)of children in the two groups were determined by using a lung function detector.The levels of CD4-positive T-lymphocytes(CD4+)and CD8-positive T-lymphocytes(CD8+)in the two groups were detected by using flow cytometry,and the CD4+/CD8+ratio was calculated.Results The total clinical effective rates of children in the control group and the observation group were 73.81％(31/42)and 95.12％(39/42),respectively;and the total effective rate of children in the observation group was significantly higher than that in the control group(P＜0.05).Before treatment,there was no statistically significant difference in the levels of TNF-α,CRP,and IL-6 of children between the two groups(P＞0.05);the levels of TNF-α,CRP,and IL-6 of children in the two groups after treatment were significantly lower than those before treatment(P＜0.05);and the levels of TNF-α,CRP,and IL-6 of children in the observation group were significantly lower than those in the control group after treatment(P＜0.05).Before treatment,there was no statistically significant difference in PEFpred,PEF,FEV1％pred,and FEV1/FVC of children between the two groups(P＞0.05);after treatment,the PEFpred,PEF,FEV1％pred,and FEV1/FVC of children in the two groups were significantly higher than those before treatment(P＜0.05);after treatment,the PEFpred,PEF,FEV,％pred,and FEV1/FVC of children in the observation group were significantly higher than those in the control group(P＜0.05).Before treatment,there was no statistically significant difference in the levels of CD4+,CD8+,and CD4+/CD8+of children between the two groups(P＞0.05);after treatment,the levels of CD4+and CD4+/CD8+of children in the two groups were significantly higher than those before treatment,while the CD8+level was significantly lower than that before treatment(P＜0.05);after treatment,the levels of CD4+and CD4+/CD8+in the observation group were significantly higher than those in the control group,while the CD8+level of children was significantly lower than that in the control group(P＞0.05).Before treatment,there was no statistically significant difference in C-ACT scores of children between the two groups(P＞0.05);after treatment,the C-ACT scores of children in the two groups were significantly higher than those before treatment(P＜0.05);the C-ACT score of children in the observation group was significantly higher than that in the control group after treatment(P＜0.05).Conclusion Yupingfeng granules combined with glucocorticoids are effective in treating children with CVA,they can reduce the inflammatory factor levels in the body,improve airway function,better control asthma symptoms,and increase the C-ACT scores.
Yupingfeng granulesglucocorticoidscough variant asthmaairway function
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