Abstract
As a new generation of artificial enzymes,nanozymes show outstanding advantages such as high stability,low cost,and facile synthesis,which endow them with promising applications in biomedical and environ-mental fields.Among the various reported nanozymes,metal-organic frameworks(MOFs)could mimic the active center of natural enzymes and provide a hydrophobic environment,which makes MOFs attractive alternatives to natural enzymes.Owing to the highly structural diversity and tailorability of MOFs,rational design will contribute to improve the activity of MOF-based nanozymes and pro-mote their potential applications in both biomedical and environmental fields.Therefore,a comprehensive summary of activity regulatory strategies of MOF-based nanozymes is urgently needed.Firstly,we summarized the activity regulatory strategies of MOFs with intrinsic enzyme-like activities via modulation of metal nodes,ligands,structures and morphologies.Then the applications of MOF-based nanozymes in biosensing,hazardous degradation,antibac-terial,and cancer therapy were also introduced.Finally,the current challenges and future perspectives were discussed in depth.It is highly expected that this review will provide a better understanding on the rational design of novel high-performance MOF-based nanozymes.
基金项目
National Natural Science Foundation of China(31901000)
National Natural Science Foundation of China(22022609)
Natural Science Foundation of Jiangsu Higher Education Institutes of China(19KJA610003)
Postdoctoral science Foundation of Jiangsu Province(2019K152)
Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions()
NETL
NSTL
万方数据