首页|Activity regulation and applications of metal-organic framework-based nanozymes

Activity regulation and applications of metal-organic framework-based nanozymes

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As a new generation of artificial enzymes,nanozymes show outstanding advantages such as high stability,low cost,and facile synthesis,which endow them with promising applications in biomedical and environ-mental fields.Among the various reported nanozymes,metal-organic frameworks(MOFs)could mimic the active center of natural enzymes and provide a hydrophobic environment,which makes MOFs attractive alternatives to natural enzymes.Owing to the highly structural diversity and tailorability of MOFs,rational design will contribute to improve the activity of MOF-based nanozymes and pro-mote their potential applications in both biomedical and environmental fields.Therefore,a comprehensive summary of activity regulatory strategies of MOF-based nanozymes is urgently needed.Firstly,we summarized the activity regulatory strategies of MOFs with intrinsic enzyme-like activities via modulation of metal nodes,ligands,structures and morphologies.Then the applications of MOF-based nanozymes in biosensing,hazardous degradation,antibac-terial,and cancer therapy were also introduced.Finally,the current challenges and future perspectives were discussed in depth.It is highly expected that this review will provide a better understanding on the rational design of novel high-performance MOF-based nanozymes.

Metal-organic frameworks(MOF)-based nanozymesActivity regulationBiosensingCancer therapyHazardous degradationAntibacterial

Ge Fang、Shou-Xin Bao、Gen-Xiu Zhou、Cui-Cui Ge

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State Key Laboratory of Radiation Medicine and Protection,School of Radiation Medicine and Protection,School for Radiological and Interdisciplinary Sciences(RAD-X),Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions,Soochow University,Suzhou 215123,China

Suzhou Nanomicro Technology Co.,Ltd,Suzhou 215000,China

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNatural Science Foundation of Jiangsu Higher Education Institutes of ChinaPostdoctoral science Foundation of Jiangsu ProvinceCollaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions

319010002202260919KJA6100032019K152

2024

10.1007/s12598-023-02311-2

稀有金属(英文版)
中国有色金属学会

稀有金属(英文版)

CSTPCDEI
影响因子：0.801
ISSN：1001-0521
年,卷(期)：2024.43(3)
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