首页|Tumor microenvironment-responsive arsenic-loaded layered double hydroxides film with synergistic anticancer and bactericidal activity
Tumor microenvironment-responsive arsenic-loaded layered double hydroxides film with synergistic anticancer and bactericidal activity
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Malignant obstruction makes gallbladder cancer have a high mortality rate.Nickel-titanium alloy(nitinol)stents are commonly used as a local intervention to maxi-mize patient survival time,but the stents lack antitumor and antibacterial capacity and are vulnerable to secondary obstruction.Arsenic-based drugs show good therapeutic promise against gallbladder cancer.To meet clinical needs,the layered double hydroxides(LDHs)film is constructed on the nitinol,whose arsenite loading amounts rose by 60％after simple heat treatment compared with the conventional anion-exchange strategy.In addition,calcination promotes the dissolution of nickel ions from the LDHs lattice,resulting in a powerful synergistic killing effect on tumor cells together with the released arsenic.More importantly,the calcined arsenic-loaded LDHs are sensitive to the acidic microenvironment of tumor tissues,which presents a much lower arsenic and nickel release amount in the nor-mal tissues,guaranteeing its biosafety.Meanwhile,the vertically sharp LDHs nanosheets can synergize with arsenic to achieve effective physical cleavage and chemical killing of adherent and planktonic bacteria.In short,we attempt to use arsenic drugs for local interventions and reasonably avoid their toxic side effects,which provides a new design idea for nitinol stents applied in the treatment of gallbladder cancer.
NitinolLayered double hydroxidesArsenicGallbladder cancer
Shun Xing、Dong-Hui Wang、Hai-Feng Zhang、Li-Dan Liu、Cheng-Ce Li、Chao Wei、Jun-Yu Liu、Nai-Jian Ge、Xuan-Yong Liu
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State Key Laboratory of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai 200050,China
Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing 100049,China
School of Health Sciences and Biomedical Engineering,Hebei University of Technology,Tianjin 300130,China
Intervention Center,Eastern Hepatobiliary Surgery Hospital,The Third Affiliated Hospital of Naval Medical University,Shanghai 200438,China
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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaScience and Technology Commission of Shanghai MunicipalityScience and Technology Commission of Shanghai Municipality
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