A direct electrochemical biosensor for rapid glucose detection based on nitrogen-doped carbon nanocages

Lan-Lan Li ¹Yu Zhao ²Li-Jia Pan ²Jian-Bin Xu ³Yi Shi²

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作者信息

1. College of Mechanical and Electrical Engineering,Henan Agricultural University,Zhengzhou 450002,China
2. School of Electronic Science and Engineering,Collaborative Innovation Center of Advanced Microstructures,Nanjing University,Nanjing 210093,China
3. Department of Electronic Engineering,The Chinese University of Hong Kong,Hong kong 999077,China
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Abstract

Given the increasing number of diabetic patients,rapid and accurate detection of glucose in body fluids is critical.This study developed a direct electro-chemical biosensor for glucose based on nitrogen-doped carbon nanocages(NCNCs).NCNCs possess a large specific surface area of 1395 m2·g-1,a high N atomic content of 9.37％and good biocompatibility,which is favorable for enzyme loading and electron transfer.The surface average concentration of electroactive glucose oxidase on NCNCs was 2.82 × 10-10 mol·cm-2.The NCNC-based direct electrochemical biosensor exhibited a high sensitivity of 13.7 μA·(mmol·L-1)-1·cm-2,rapid response time of 5 s and an impressive electron-transfer-rate constant(ks)of 1.87 s-1.Furthermore,we investigated an NCNC-based direct electron transfer(DET)biosensor for sweat glucose detection,which demonstrated tremen-dous promise for non-invasive wearable diabetes diagnosis.

Key words

Direct electron transfer(DET)/Nitrogen-doped carbon nanocages(NCNCs)/Glucose oxidase/Biosensor

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基金项目

National Key Research and Development Program of China(2021YFA1401103)

National Natural Science Foundation of China(61825403)

National Natural Science Foundation of China(61921005)

National Natural Science Foundation of China(61904049)

出版年

2024

稀有金属(英文版)

中国有色金属学会

稀有金属(英文版)

CSTPCDEI

影响因子：0.801

ISSN：1001-0521

参考文献量54

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