Abstract
Although chemotherapy has been intensively applied in cancer treatments,its inadequate therapeutic efficacy and severe side effects are still under constant concerns.Nanoplatforms used as anti-tumor drug delivery system(DDS)have attracted tremendous attentions owing to their various intriguing properties.Herein,Mn-doped MoO2 nanoparticles coated with ZrO2 and capped with Bi2O3 have been designed as a DDS,namely MMZB.MMZB possesses good magnetic properties,great pho-tothermal conversion ability,sensitive tumor microenvi-ronment(TME)responsiveness,and good biocompatibility in hemocompatibility in vitro.Thus,MMZB has been utilized to load the chemotherapeutic agent daunomycin(DNM)(MMZB@DNM)for chemo-photothermal com-bined therapy.MMZB@DNM demonstrates a more impressive anti-cancer effect than the individual pho-tothermal or chemotherapy both in vitro and in vivo.Fur-thermore,the analysis of tumor specimen sections and serum levels after the treatment indicates negligible side effects for MMZB@DNM in vivo.This contribution pro-vides a valuable concept in designing therapeutic agents for achieving significantly enhanced tumor treatments,which benefits from the synergistic combination of chemotherapy and photothermal therapy in one single nanoagent.
基金项目
National Natural Science Foundation of China(22271178)
National Natural Science Foundation of China(22001156)
Project of Special Key Fields in Guangdong Province(2021ZDZX4019)
Science and technology innovation strategy of Guangdong province(51361212)
Guangdong Provincial Science and Technology Innovation Strategy Special Fund Approval Project(pdjh2021b0266)
NETL
NSTL
万方数据