Abstract
Photodynamic therapy(PDT),with high spa-tiotemporal selectivity,minimal side effects and less drug resistance,has emerged as a promising approach for the treatment of cancer.However,inadequate penetration depth and poor efficacy seriously restrict its practical application.To address these challenges,we developed a combined therapy platform(RENP@C/D-FA)based on rare-earth-doped nanoparticles(RENPs)with a structure of NaErF4∶Tm(0.5％)@NaYF4,on which photosensitizer Ce6(chlorin e6)and chemo-therapeutic drug(DOX)(doxoru-bicin)were loaded by encapsulating with an amphiphilic polymer distearoyl phosphatidylethanolamine-poly-ethylene glycol-folic acid(DSPE-PEG-FA).RENPs with NaErF4 as the matrix possess multiple excitation/emission peaks,enabling activation of PDT under near-infrared-Ⅱb(NIR-Ⅱb,1500-1700 nm)excitation and luminescence imaging in NIR-Ⅱb region by absorbing 808 nm near-in-frared photons.Furthermore,DOX can be selectively released in the acidic microenvironment of tumors.Bene-fiting from the tumor targeting capability of folic acid,this platform can successfully ablate tumor cells and inhibit tumor growth by combining PDT and chemotherapy.This innovative approach holds great promise as a powerful tool for cancer treatment,showing the potential to revolutionize PDT.
基金项目
National Natural Science Foundation of China(22004133)
National Natural Science Foundation of China(22174035)
Hubei Province Outstanding Youth Foundation(2022CFA082)
NETL
NSTL
万方数据