Abstract
Cisplatin resistance is the main cause for the failure of cancer therapy.To solve the problem,we pro-posed to develop a novel human serum albumin(HSA)nanoplatform to integrate chemotherapy,photothermal therapy(PTT)and immunotherapy.To this end,we obtained a platinum compound(C5)with significant cytotoxicity in the cisplatin-resistant SKOV-3 cells(SKOV-3/DDP),and then innovatively constructed photo-sensitizer(indocyanine green(ICG))-encapsulated HSA-C5 complex nanoparticles(ICG@HSA-C5 NPs).The ICG@HSA-C5 NPs exhibited excellent photothermal per-formances in vitro and in vivo.Importantly,the in vivo results revealed that HSA enhanced the antitumor effect of C5 and that the combination of chemotherapy and PTT could significantly inhibit cisplatin-resistant tumor growth and improved the targeting abilities of C5 and ICG,and reduced their side effects.We also confirmed that ICG@HSA-C5 NPs killed the SKOV-3/DDP cells via gasdermin E(GSDME)-mediated pyroptosis andpyroptosis-induced immune responses,thereby synergisti-cally leading to the death of the SKOV-3/DDP cells.
维普
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