Introduction of the 2023 Nobel Prize in Physiology or Medicine:Nucleoside Base Modification and mRNA Vaccine
The 2023 Nobel Prize in Physiology or Medicine was awarded to Katalin KARIKÓ and Drew WEISSMAN for their discovery of nucleoside base modification.The study of two scientists found that in vitro transcribed mRNA with modified bases can escape adverse immune reaction and also found that mRNA containing pseudouridine can be translated more effectively.Based on the research of two scientists,the delivery systems have been developed efficiently.The nucleoside modification,mRNA vaccine,lipid nanoparticles,mRNA vaccine application prospect were introduced.
Nobel Prize in Physiology or MedicinemRNA vaccinenucleoside modificationlipid nanoparticlesSARS-CoV-2 vaccine
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