Apreliminary study on the Open,Randomized,Parallel and Controlled clinical effi-cacy of Tibetan medicine in the Treatment of novel coronavirus infection
Objective To observe the preliminary clinical efficacy of Tibetan medicine in the treatment of nucleic ac-id conversion rate and improvement of clinical symptoms of novel coronavirus infection.Methods This study is di-vided into two phases,namely preliminary observation and further confirmation.The total sample size in the prelimi-nary observation stage was 1,000 cases.According to the principles of randomization,openness,parallelism,and con-trol,the patients were randomly divided into 4 groups of treatment regimens through a random number table,and fi-nally 738 patients completed the efficacy evaluation after a group of patients who took the combination of Lianhua Qingwen Capsule and Golden Throat was exclueded.The main indicators of observation were the time period of neg-ative conversion of nucleic acid positive indicators,and the secondary indicators were the changes in nucleic acid CT values and the improvement of clinical symptoms.In the further confirmation stage,the total sample size was 631 cases,which were divided into two groups of treatment regimens according to the principles of randomization,open-ness,parallelism,and control.In the end after eliminating the patients with poor compliance or incomplete clinical da-ta,a total of 603 patients completed the efficacy evaluation,with the main indicators of observation that were the time period of the positive nucleic acid index turning negative,and the secondary indicators that were the change in the nu-cleic acid CT value and the improvement of clinical symptoms.Results The median nucleic acid conversion time of the four groups in the initial observation stage was 6 days,7 days,6 days,and 7 days respectively.The rates of nucle-ic acid conversion within 7 days were 64.32％,67.98％,64.21％,and 68.11％respectively,with no statistical signifi-cance between groups(P＞0.05).Tibetan medicine could significantly improve clinical symptoms of the four groups,but there was no statistical significance between the groups(P＞0.05).The median time to negative nucleic acid con-version of the two treatment regimens in the further confirmation stage was 3 days.The nucleic acid conversion rate within 7 days were 75.84％and 82.95％respectively.The cumulative nucleic acid conversion rate within 7 days of the second group was significantly higher than that of the first group(P＜0.05).Conclusion The treatment of novel coronavirus infection with Tibetan medicine can shorten the time for nucleic acid conversion to negative,reduce the rate of severe conversion in asymptomatic and mild patients,and has significant clinical efficacy and few adverse re-actions,which is worthy of popularization.
Novel coronavirus infectionTibetan medicineClinical research
万方数据
维普
