Clinical Analysis of 299 Cases of Hyperbilirubinemia in Tibetan Neonates on Plateau
Objective To analyze the occurrence,peak bilirubin,and etiology of neonatal hyperbilirubinemia in our hospital in the past two years,to provide data for the study of high-altitude neonatal bilirubin,and to provide a basis for the prevention and standardized management of neonatal bilirubinemia.Methods The study retrospectively sum-marized the Tibetan near-term Tibetan infants(>35 weeks of gestation)who presented to the Department of Pediatrics of the People's Hospital of Xizang Autonomous Region from January 2019 to July 2021 with jaundice-related com-plaints,and described the distribution of bilirubin peaks,comparisons between different gestational ages,analysis of comorbidities,and characterization of children with encephalopathy.Results Among the 299 cases of neonatal hyper-bilirubinemia,109 cases(35.8%)were severe hyperbilirubinemia and 6 cases of acute bilirubinous encephalopathy,accounting for 5.7%of severe hyperbilirubinemia.The age of jaundice was 4 days(range:1～26 days),the average age of admission was 7 days(range:1～30 days),and the peak TSB was 342.45±65.23 μmol/L.Ninety-one percent of the included cases had varying degrees of infection,and two had ABO autoimmune hemolysis.Conclusion The data of this study showed the peak distribution of bilirubin in Tibetan near-term neonates,and the proportion of infants with severe hyperbilirubinemia and encephalopathy was relatively high,suggesting that the audience of neonatal jaundice related scientific knowledge should be expanded,and a systematic and comprehensive follow-up should be established to provide a basis for the prevention and standardized management of severe hyperbilirubinemia.
万方数据
维普
