Effect Analysis of 20 Cases of Intravenous Thrombolysis Bridgeing Intra-arterial Thrombectomy in the treatment of Acute Intracranial Large Vessel Occlusionin Xizang
Objective The essay is to discuss the efficacy of intravenous thrombolytic bridging intra-arterial throm-bectomy in the treatment of patients with acute intracranial large vessel occlusion in the Tibetan Region.Methods A retrospective analysis was conducted on the clinical data of 20 patients with acute intracranial aortic occlusion and in-travenous thrombolysis bridging intra-arterial thrombectomy from October 2019 to December 2023 in People's Hos-pital of Xizang Autonomous Region.Among the cases,5 patients had isolated middle cerebral artery(MCA)occlu-sion,4 patients had basilar artery occlusion,8 patients had internal carotid artery(ICA)occlusion,and 3 patients had MCA with ICA occlusion.Data analyzed included age,ethnicity,altitude,DNT(time from stroke onset to thromboly-sis),recanalizaiton time of blood vessels,number of thrombectomy,postoperative recanalization effect,admission NI-HSS(National Health Centers Stroke Scale)score,discharge NIHSS score,admission GCS(Glasgow Coma Scale)score,and discharge mRS(modified Rankin Scale)score.Results Among the 20 patients with acute intracranial ar-tery occlusion,all of them successfully opened the occluded blood vessels,and the blood flow of the occluded blood vessels reached the eTICI grade≥2b50,and 4 patients had hemorrhagic transformation complications after thrombec-tomy and were given a second craniotomy.Based on 90-day mRS scores,patients were grouped into good prognosis(0～2 points)and poor prognosis(3～6 points)with no significant differences in gender,age,altitude,DNT,reperfusion time,or number of thrombectomy attempts(P>0.05).Statistically significant differences were observed in admission NIHSS,admission GCS,and discharge NIHSS scores between the groups(P<0.05).Conclusion Patients with intra-venous thrombolysis bridging intra-arterial thrombectomy in Xizang can achieve a good revascularization rate(100％),and the prognosis of pre-treatment circulation vascular occlusion is better than that of patients with posterior circulation vascular occlusions.
Acute large vessel occlusionStrokeEndovascular treatmentThrombectomy
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NSTL
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