Problems and countermeasures in the ESG information disclosure of the Stationery Industry
Objective Low pressure,low oxygen,coldness,strong ultraviolet rays,and dryness are the unique envi-ronments of the plateau.In the environment of rapid entry into the altitude more than 2500 m,the pulmonary arteryi pressure is easy to increase,which in turn increases pulmonary blood volume,leading to the exudation offluid in the capillaries to the pulmonary interstitium and alveoli,alveolar and interstitial edema,intraalveolar fibrin exudation and hyaline membrane formation,extreme dilatation and congestion of pulmonary capillaries and a reduced alveolar clearanceability,resulting in high-altitude pulmonary edema(HAPE).At present,there is no perfect biomarker for the diagnosis of HAPE,which prompts researchers to continue to explore and try various innovative methods in order to discover new and effective biomarkers.This exploration has become a popular trend in the field of HAPE research.In this study,metabolomics technology was used to analyze the small molecule metabolites in plasma of patients with HAPE and normal controls,in order to seek potential markers of HAPE.Methods Liquid chromatography tandem mass spectrometry(LC-MS/MS)was used to analyze the plasma samples of 30 patients with HAPE and 30 normal controls who rushed to Xizang,and the orthogonal partial least squares(OPLS-DA)method was used to construct the model.The differential metabolites in the plasma samples of the two groups were explored by the two-sample test.Results A total of 3184 metabolites were identified in plasma,and multivariate analysis revealed significant differ-ences in metabolite levels between the two groups,and 143 metabolites related to plasma differences were identified based on statistical tests.Conclusion Metabolomics is expected to detect sensitive and specific biomarkers,which will revolutionize the diagnosis and treatment of HAPE.
High altitude pulmonary edema(HAPE)MetabolomicsLiquid chromatography mass spectrometry(LC-MS)Biomarkers
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