Objective To analyze the risk factors of post-ERCP pancreatitis(PEP)and hyperamylasemia(PEHA)in Lhasa region.Methods A total of 414 patients who underwent ERCP in our hospital from January 2018 to January 2021 were selected.The patients with PEP after surgery were set as the observation group(97 cases),and the patients with PEHA were set as the control group(317 cases).The relationship between general data,auxiliary examination,surgical operation information and PEP,PEHA of the two groups was analyzed.Results The incidence of PEP and PEHA was 9.4%and 14%,respectively.The risk fac-tors of PEP included age<60 years,female,endoscopic sphincterotomy(EST)and 24h postoperative white blood cell count(WBC).Conclusion The indications of ERCP should be strictly controlled,the high-risk patients should be identified,and early preventive measures should be taken to reduce the conversion of PEHA to PEP and the occurrence of severe PEP.