Rheumatoid arthritis is a common chronic,systemic inflammatory autoimmune disease characterized by persistent joint pain,swelling,stiffness,and damage to cartilage.It greatly affects the normal life of patients.As a small molecule secreted cytokine,CX3CL1 has chemotaxis and adhesion functions that mediate cell migration and adhesion by interacting with cell surface G protein-coupled receptors.A large number of studies have shown that the CX3CL1-CX3CR1 axis participates in the formation and develop-ment of rheumatoid arthritis through multiple pathways.Therefore,this study provides an overview and analysis of the role of CX3CL1-CX3CR1 axis in rheumatoid arthritis.
维普
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