摘要
目的 分析宫颈HSIL锥切术后切缘阳性的相关因素.方法回顾性分析2016年1月～2020年12月病理确诊的宫颈HSIL并行宫颈锥切的患者776例.分析治疗方式、年龄、累及腺体、HPV感染、多点病变与切缘阳性的相关性.结果776例患者锥切术后切缘阳性143例(18.32％);单因素分析显示宫颈HSIL锥切术后切缘阳性与LEEP手术(P＜0.05)、累及腺体(P＜0.01)、多点病变(P＜0.05)有关,与HPV感染(P＞0.05)、年龄(P＞0.05)无关;多因素回归分析显示LEEP手术、累及腺体及宫颈多点病变是宫颈HSIL锥切术后切缘阳性的独立危险因素(P＜0.05).结论LEEP手术、累及腺体及宫颈多点病变是宫颈HSIL锥切术后切缘阳性的高危因素,在治疗上要引起重视.
Abstract
Objective To analyze the related causes of high grade squamous intraepithelial lesion(HSIL)with positive margin af-ter cervical conization.Methods From January 2016 to December 2020,776 patients with cervical HSIL and conectomy were retro-spectively analyzed.The correlation of treatment,age,glands involved,HPV infection,multipoint lesions and positive incisal mar-gin were analyzed.Results Of 776 patients,143(18.32％)had positive margins after cone resection.Univariate analysis showed that positive incisal margin after HSIL conectomy was associated with LEEP surgery(P＜0.05),involved glands(P＜0.01)and multi-point lesions(P＜0.05),but not HPV infection(P＞0.05)or age(P＞0.05).Multivariate regression analysis showed that LEEP sur-gery,glandular involvement and multiple cervical lesions were independent risk factors for positive incisal margin after HSIL conec-tomy(P＜0.05).Conclusion LEEP surgery,glandular involvement and cervical multipoint lesions are high risk factors for positive margin after HSIL conectomy.Attention should be paid to the treatment.
维普
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