Objective To investigate the effect of dexamethasone on postoperative delirium(POD)in patients with high altitude after knee replacement.Methods From January 2018 to December 2022,842 patients underwent knee replacement under general anesthesia in our hospital.According to whether dexamethasone was used intravenously before operation,the patients in the dexa-methasone group(460 cases)received intravenous dexamethasone before operation,and the control group(382 cases)did not re-ceive dexamethasone before operation.The incidence of delirium within 7 days after operation was compared between the two groups.Results POD occurred in 44 cases(9.6％)in dexamethasone group and 56 cases(14.7％)in control group,with statistical difference(P=0.014).Multivaiate logistic regression model adjusted for confounders:intravenous dexamethasone reduced the risk of POD in knee replacement patients with high altitude(P=0.030).Conclusion Preoperative intravenous dexamethasone cloud re-duce the risk of POD in patients undergoing knee arthroplasty under elective general anesthesia.
维普
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